Not sure how clear my understanding is but I have a few of the pieces. It depends on the type bottle and the solution you use in the bottle. Many bottles that come sealed are throw-aways. Once the seal is broken they are to be discarded and replaced. They are not refillable. These are also to be replaced at the expiration date.
For refillable bottles, it depends on what you use. You can use straight tap water if you refill them weekly. If you use tap water and a preservative, you will need to follow the manufacturer's recommendations. You may need to test for bacteria before you try to stretch it to the maximum recommended. You can also purchase the solution. Follow the manufacturer's recommendation for this. The replacement frequency varies.
A common practice used to be to use distilled water and sterilize the bottles when refilling. Refill intervals for this was monthly. I can't seem to find a reference to back this up right now, but it makes sense when compared to the weekly interval for straight tap water.
We have gone to the factory sealed bottles. The man-hours are too valuable to spend them refilling bottles.